292437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2143563..2144092 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQM91_RS11360 Protein ID WP_000621175.1
Coordinates 2143563..2143925 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQM91_RS11365 Protein ID WP_000948331.1
Coordinates 2143922..2144092 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS11335 2140553..2141323 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
DQM91_RS11340 2141298..2141777 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQM91_RS11345 2141779..2142105 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQM91_RS11350 2142224..2143214 - 991 Protein_2094 PP2C family protein-serine/threonine phosphatase -
DQM91_RS11360 2143563..2143925 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQM91_RS11365 2143922..2144092 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQM91_RS11370 2144177..2145325 - 1149 WP_001281145.1 alanine racemase -
DQM91_RS11375 2145391..2145750 - 360 WP_000581200.1 holo-ACP synthase -
DQM91_RS11380 2145754..2146245 - 492 WP_001205910.1 PH domain-containing protein -
DQM91_RS11385 2146232..2147815 - 1584 WP_001294626.1 PH domain-containing protein -
DQM91_RS11390 2147808..2148287 - 480 WP_001287088.1 hypothetical protein -
DQM91_RS11395 2148496..2149056 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292437 WP_000621175.1 NZ_LS483365:c2143925-2143563 [Staphylococcus aureus subsp. aureus NCTC 8325]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292437 WP_000948331.1 NZ_LS483365:c2144092-2143922 [Staphylococcus aureus subsp. aureus NCTC 8325]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References