Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1899280..1900056 Replicon chromosome
Accession NZ_LS483365
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQM91_RS09675 Protein ID WP_000031108.1
Coordinates 1899280..1899432 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQM91_RS09680 Protein ID WP_001251224.1
Coordinates 1899457..1900056 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM91_RS09650 1895243..1896064 + 822 WP_000669376.1 RluA family pseudouridine synthase -
DQM91_RS09655 1896527..1897912 - 1386 WP_000116224.1 class II fumarate hydratase -
DQM91_RS09660 1898108..1898503 - 396 WP_000901021.1 hypothetical protein -
DQM91_RS09675 1899280..1899432 - 153 WP_000031108.1 hypothetical protein Toxin
DQM91_RS09680 1899457..1900056 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQM91_RS09685 1900215..1900685 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQM91_RS09690 1900690..1901817 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
DQM91_RS09695 1901968..1902690 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQM91_RS09700 1902683..1904140 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292433 WP_000031108.1 NZ_LS483365:c1899432-1899280 [Staphylococcus aureus subsp. aureus NCTC 8325]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292433 WP_001251224.1 NZ_LS483365:c1900056-1899457 [Staphylococcus aureus subsp. aureus NCTC 8325]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References