Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 272278..272890 Replicon chromosome
Accession NZ_LS483363
Organism Streptococcus dysgalactiae subsp. equisimilis strain NCTC9414

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag DQM58_RS01520 Protein ID WP_000384859.1
Coordinates 272278..272613 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID G5KDE1
Locus tag DQM58_RS01525 Protein ID WP_006738697.1
Coordinates 272603..272890 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM58_RS01495 268002..268436 + 435 WP_001220480.1 hypothetical protein -
DQM58_RS01500 268753..270009 + 1257 WP_111681514.1 plasmid recombination protein -
DQM58_RS01505 270177..270665 + 489 WP_111681515.1 hypothetical protein -
DQM58_RS01510 270711..271844 + 1134 WP_022554244.1 ISAs1-like element IS1548 family transposase -
DQM58_RS01520 272278..272613 - 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM58_RS01525 272603..272890 - 288 WP_006738697.1 hypothetical protein Antitoxin
DQM58_RS01530 273101..273184 + 84 Protein_248 30S ribosomal protein S9 -
DQM58_RS01535 273295..274515 - 1221 WP_111681516.1 tyrosine-type recombinase/integrase -
DQM58_RS01540 274584..274844 - 261 WP_111681517.1 helix-turn-helix domain-containing protein -
DQM58_RS01545 274822..275421 - 600 WP_111681518.1 replication protein -
DQM58_RS01550 275612..276223 - 612 WP_070811395.1 hypothetical protein -
DQM58_RS01555 276223..277299 - 1077 WP_111681949.1 cell division protein FtsK -
DQM58_RS01560 277309..277586 - 278 Protein_254 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 270711..271844 1133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T292426 WP_000384859.1 NZ_LS483363:c272613-272278 [Streptococcus dysgalactiae subsp. equisimilis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10878.45 Da        Isoelectric Point: 4.7271

>AT292426 WP_006738697.1 NZ_LS483363:c272890-272603 [Streptococcus dysgalactiae subsp. equisimilis]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G5KDE1

References