Detailed information of TA system TA292425

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 666805..668228
• Replicon: chromosome
• Accession: NZ_LS483361
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6179

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: DQM53_RS03630
• Protein ID: WP_111715775.1
• Coordinates: 666805..667641 (-)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: DQM53_RS03635
• Protein ID: WP_111715777.1
• Coordinates: 667638..668228 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQM53_RS03605	662102..662314	+	213	WP_111715768.1	YdbC family protein	-
DQM53_RS11220	662417..662557	-	141	WP_003049996.1	hypothetical protein	-
DQM53_RS03610	662609..663736	-	1128	WP_111715770.1	NAD(P)-binding domain-containing protein	-
DQM53_RS03615	663840..664877	+	1038	WP_111715772.1	ammonium transporter	-
DQM53_RS03620	665108..666358	-	1251	WP_101750348.1	site-specific integrase	-
DQM53_RS03625	666423..666620	-	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
DQM53_RS03630	666805..667641	-	837	WP_111715775.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
DQM53_RS03635	667638..668228	-	591	WP_111715777.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
DQM53_RS03640	668341..669453	-	1113	WP_111715780.1	CHAP domain-containing protein	-
DQM53_RS03645	669472..669699	-	228	WP_101750352.1	hypothetical protein	-
DQM53_RS03650	669686..671596	-	1911	WP_111715782.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	665108..690450	25342

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31937.34 Da
• Isoelectric Point: 5.1824

>T292425 WP_111715775.1 NZ_LS483361:c667641-666805 [Streptococcus dysgalactiae subsp. equisimilis]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDIYILSKLKKSEIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23193.56 Da
• Isoelectric Point: 8.3205

>AT292425 WP_111715777.1 NZ_LS483361:c668228-667638 [Streptococcus dysgalactiae subsp. equisimilis]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGIISIKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp