Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1631021..1631633 Replicon chromosome
Accession NZ_LS483360
Organism Streptococcus pyogenes strain NCTC10876

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQM47_RS08450 Protein ID WP_002982731.1
Coordinates 1631298..1631633 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM47_RS08445 Protein ID WP_002988079.1
Coordinates 1631021..1631308 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM47_RS08420 1626200..1627183 - 984 WP_023610648.1 tagatose-bisphosphate aldolase -
DQM47_RS08425 1627187..1628116 - 930 WP_023610632.1 tagatose-6-phosphate kinase -
DQM47_RS08430 1628164..1628679 - 516 WP_002982748.1 galactose-6-phosphate isomerase subunit LacB -
DQM47_RS08435 1628714..1629142 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQM47_RS08440 1629587..1630360 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM47_RS08445 1631021..1631308 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM47_RS08450 1631298..1631633 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM47_RS09950 1631761..1632255 + 495 WP_032465896.1 site-specific integrase -
DQM47_RS09955 1632218..1632580 + 363 WP_180372423.1 tyrosine-type recombinase/integrase -
DQM47_RS09960 1632616..1632765 + 150 WP_011285175.1 integrase -
DQM47_RS08460 1633137..1634348 - 1212 WP_013851451.1 hypothetical protein -
DQM47_RS08465 1634550..1635422 + 873 WP_023610636.1 hypothetical protein -
DQM47_RS08470 1635437..1635907 + 471 WP_111695860.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1610775..1643481 32706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292424 WP_002982731.1 NZ_LS483360:1631298-1631633 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292424 WP_002988079.1 NZ_LS483360:1631021-1631308 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References