Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2067342..2068057 Replicon chromosome
Accession NZ_LS483358
Organism Actinobacillus pleuropneumoniae strain NCTC11384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DQM70_RS09880 Protein ID WP_005609264.1
Coordinates 2067342..2067770 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag DQM70_RS09885 Protein ID WP_005599447.1
Coordinates 2067770..2068057 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM70_RS09865 2062927..2064633 - 1707 WP_005606484.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
DQM70_RS09870 2064729..2065010 - 282 WP_005599441.1 DNA-directed RNA polymerase subunit omega -
DQM70_RS09875 2065137..2067218 - 2082 WP_005606488.1 ATP-dependent DNA helicase RecG -
DQM70_RS09880 2067342..2067770 - 429 WP_005609264.1 type II toxin-antitoxin system VapC family toxin Toxin
DQM70_RS09885 2067770..2068057 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQM70_RS09890 2068263..2069978 + 1716 WP_005606494.1 proline--tRNA ligase -
DQM70_RS09895 2070044..2070232 - 189 WP_005602684.1 hypothetical protein -
DQM70_RS09900 2070235..2070816 - 582 WP_005606496.1 sigma-70 family RNA polymerase sigma factor -
DQM70_RS09905 2070905..2071861 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
DQM70_RS09910 2071861..2072454 + 594 WP_005606498.1 sulfoxide reductase heme-binding subunit YedZ -
DQM70_RS09915 2072646..2072864 - 219 Protein_1890 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16455.92 Da        Isoelectric Point: 8.2641

>T292422 WP_005609264.1 NZ_LS483358:c2067770-2067342 [Actinobacillus pleuropneumoniae]
MFQYLFDTNIISELYKLGSNRMDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQA
KSFSINNEIALLASEYHIPNKMDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT292422 WP_005599447.1 NZ_LS483358:c2068057-2067770 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References