Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1761344..1762075 Replicon chromosome
Accession NZ_LS483358
Organism Actinobacillus pleuropneumoniae strain NCTC11384

Toxin (Protein)


Gene name tacT Uniprot ID B0BRD2
Locus tag DQM70_RS08240 Protein ID WP_005605461.1
Coordinates 1761344..1761811 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag DQM70_RS08245 Protein ID WP_005619269.1
Coordinates 1761815..1762075 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM70_RS08215 1756699..1757070 - 372 WP_005605451.1 CrcB family protein -
DQM70_RS08220 1757073..1758137 - 1065 WP_043990971.1 MFS transporter -
DQM70_RS08225 1758232..1759341 + 1110 WP_005605455.1 anhydro-N-acetylmuramic acid kinase -
DQM70_RS08230 1759395..1760309 + 915 WP_005605457.1 N-acetylmuramic acid 6-phosphate etherase -
DQM70_RS08235 1760379..1761260 - 882 WP_043990972.1 50S ribosomal protein L11 methyltransferase -
DQM70_RS08240 1761344..1761811 - 468 WP_005605461.1 GNAT family N-acetyltransferase Toxin
DQM70_RS08245 1761815..1762075 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
DQM70_RS08250 1762196..1763656 - 1461 WP_005605463.1 metalloprotease TldD -
DQM70_RS08255 1763786..1765045 + 1260 WP_005605465.1 tRNA lysidine(34) synthetase TilS -
DQM70_RS08260 1765072..1765362 - 291 WP_005598848.1 DUF5389 family protein -
DQM70_RS08265 1765364..1766257 - 894 WP_005605467.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17276.25 Da        Isoelectric Point: 9.5125

>T292421 WP_005605461.1 NZ_LS483358:c1761811-1761344 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVRDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNQQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT292421 WP_005619269.1 NZ_LS483358:c1762075-1761815 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BRD2

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References