Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1556365..1557010 Replicon chromosome
Accession NZ_LS483358
Organism Actinobacillus pleuropneumoniae strain NCTC11384

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag DQM70_RS07230 Protein ID WP_005619674.1
Coordinates 1556639..1557010 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQM70_RS07225 Protein ID WP_005598477.1
Coordinates 1556365..1556658 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM70_RS07195 1551697..1552380 - 684 WP_005605188.1 arginine ABC transporter permease ArtM -
DQM70_RS07200 1552380..1553051 - 672 WP_005605189.1 arginine ABC transporter permease ArtQ -
DQM70_RS07205 1553057..1553791 - 735 WP_005605190.1 transporter substrate-binding domain-containing protein -
DQM70_RS07210 1553796..1554530 - 735 WP_005605201.1 arginine ABC transporter ATP-binding protein ArtP -
DQM70_RS07215 1554755..1555252 - 498 WP_005601953.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
DQM70_RS07220 1555325..1556287 + 963 WP_005619672.1 calcium/sodium antiporter -
DQM70_RS07225 1556365..1556658 - 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
DQM70_RS07230 1556639..1557010 - 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM70_RS07235 1557204..1558955 + 1752 WP_005601957.1 protein-disulfide reductase DsbD -
DQM70_RS07240 1559013..1559582 + 570 WP_005605204.1 elongation factor P hydroxylase -
DQM70_RS07245 1559626..1560480 - 855 WP_005605207.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T292420 WP_005619674.1 NZ_LS483358:c1557010-1556639 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT292420 WP_005598477.1 NZ_LS483358:c1556658-1556365 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References