Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1106281..1106873 Replicon chromosome
Accession NC_020796
Organism Edwardsiella tarda C07-087

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag ETAC_RS04850 Protein ID WP_012847872.1
Coordinates 1106281..1106484 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag ETAC_RS04855 Protein ID WP_015461125.1
Coordinates 1106505..1106873 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAC_RS04825 1101978..1102439 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
ETAC_RS04830 1102744..1103082 + 339 WP_012847867.1 P-II family nitrogen regulator -
ETAC_RS04835 1103104..1104384 + 1281 WP_041692495.1 ammonium transporter AmtB -
ETAC_RS04840 1104419..1105285 - 867 WP_012847869.1 acyl-CoA thioesterase II -
ETAC_RS04845 1105395..1105751 - 357 WP_041692719.1 MGMT family protein -
ETAC_RS04850 1106281..1106484 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
ETAC_RS04855 1106505..1106873 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
ETAC_RS04860 1107241..1110393 - 3153 WP_012847874.1 multidrug efflux RND transporter permease subunit -
ETAC_RS04865 1110437..1111621 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T29242 WP_012847872.1 NC_020796:c1106484-1106281 [Edwardsiella piscicida C07-087]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T29242 NC_020796:c1106484-1106281 [Edwardsiella piscicida C07-087]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT29242 WP_015461125.1 NC_020796:c1106873-1106505 [Edwardsiella piscicida C07-087]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT29242 NC_020796:c1106873-1106505 [Edwardsiella piscicida C07-087]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGTTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References