Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1461259..1461767 Replicon chromosome
Accession NZ_LS483358
Organism Actinobacillus pleuropneumoniae strain NCTC11384

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag DQM70_RS06745 Protein ID WP_005605064.1
Coordinates 1461507..1461767 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A3N1S6
Locus tag DQM70_RS06740 Protein ID WP_005605062.1
Coordinates 1461259..1461510 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM70_RS06695 1456671..1457219 - 549 WP_005605049.1 type IV pilus biogenesis/stability protein PilW -
DQM70_RS06700 1457273..1458454 - 1182 WP_005605050.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
DQM70_RS06730 1459482..1460921 + 1440 WP_005605060.1 glutamate--tRNA ligase -
DQM70_RS06740 1461259..1461510 + 252 WP_005605062.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
DQM70_RS06745 1461507..1461767 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
DQM70_RS06750 1461926..1462093 - 168 WP_005605066.1 Trm112 family protein -
DQM70_RS06755 1462095..1463075 - 981 WP_005605069.1 tetraacyldisaccharide 4'-kinase -
DQM70_RS06760 1463170..1464429 - 1260 WP_111705952.1 ATP-dependent protease ATP-binding subunit ClpX -
DQM70_RS06765 1464429..1465019 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
DQM70_RS06770 1465141..1465533 + 393 WP_005620423.1 SufE family protein -
DQM70_RS06785 1465892..1466665 - 774 WP_043990950.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T292419 WP_005605064.1 NZ_LS483358:1461507-1461767 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9320.62 Da        Isoelectric Point: 4.5659

>AT292419 WP_005605062.1 NZ_LS483358:1461259-1461510 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB A3N1S6

References