Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 834744..835394 Replicon chromosome
Accession NZ_LS483358
Organism Actinobacillus pleuropneumoniae strain NCTC11384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DQM70_RS03850 Protein ID WP_005604115.1
Coordinates 835005..835394 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BNU4
Locus tag DQM70_RS03845 Protein ID WP_005604117.1
Coordinates 834744..835004 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM70_RS03825 829764..830384 - 621 WP_005596976.1 hypothetical protein -
DQM70_RS03830 830395..831588 - 1194 WP_005604123.1 deferrochelatase/peroxidase EfeB -
DQM70_RS03835 831600..832412 - 813 WP_005604121.1 EfeM/EfeO family lipoprotein -
DQM70_RS03840 832589..834610 + 2022 WP_005604119.1 excinuclease ABC subunit B -
DQM70_RS03845 834744..835004 + 261 WP_005604117.1 hypothetical protein Antitoxin
DQM70_RS03850 835005..835394 + 390 WP_005604115.1 type II toxin-antitoxin system VapC family toxin Toxin
DQM70_RS03855 835530..836753 + 1224 WP_005604113.1 ATP-binding protein -
DQM70_RS03860 836879..840153 + 3275 Protein_749 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14895.21 Da        Isoelectric Point: 4.8482

>T292418 WP_005604115.1 NZ_LS483358:835005-835394 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALETECVLVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.63 Da        Isoelectric Point: 5.1867

>AT292418 WP_005604117.1 NZ_LS483358:834744-835004 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N030

References