Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1683754..1684366 Replicon chromosome
Accession NZ_LS483356
Organism Streptococcus pyogenes strain NCTC8230

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQM51_RS08930 Protein ID WP_111713386.1
Coordinates 1684031..1684366 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM51_RS08925 Protein ID WP_002988079.1
Coordinates 1683754..1684041 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM51_RS08900 1678943..1679926 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
DQM51_RS08905 1679930..1680859 - 930 WP_002982751.1 tagatose-6-phosphate kinase -
DQM51_RS08910 1680907..1681422 - 516 WP_111713385.1 galactose-6-phosphate isomerase subunit LacB -
DQM51_RS08915 1681457..1681885 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQM51_RS08920 1682331..1683104 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM51_RS08925 1683754..1684041 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM51_RS08930 1684031..1684366 + 336 WP_111713386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM51_RS08935 1684455..1685499 + 1045 Protein_1658 site-specific integrase -
DQM51_RS08945 1685631..1686023 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM51_RS08950 1686044..1686490 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM51_RS08955 1686677..1687654 - 978 WP_038433791.1 IS30-like element IS1239 family transposase -
DQM51_RS08960 1687794..1688000 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM51_RS08965 1687997..1688503 - 507 WP_002988070.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1686677..1687654 977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13045.77 Da        Isoelectric Point: 5.6658

>T292416 WP_111713386.1 NZ_LS483356:1684031-1684366 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGGENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292416 WP_002988079.1 NZ_LS483356:1683754-1684041 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References