Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1513830..1514442 Replicon chromosome
Accession NZ_LS483355
Organism Streptococcus pyogenes strain NCTC12067

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL02_RS07720 Protein ID WP_002994716.1
Coordinates 1514107..1514442 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL02_RS07715 Protein ID WP_002988079.1
Coordinates 1513830..1514117 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL02_RS07690 1509009..1509992 - 984 WP_031488719.1 tagatose-bisphosphate aldolase -
DQL02_RS07695 1509996..1510925 - 930 WP_031488720.1 tagatose-6-phosphate kinase -
DQL02_RS07700 1510973..1511488 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQL02_RS07705 1511523..1511951 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQL02_RS07710 1512396..1513169 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL02_RS07715 1513830..1514117 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL02_RS07720 1514107..1514442 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL02_RS08945 1514594..1515064 + 471 WP_021733374.1 site-specific integrase -
DQL02_RS08950 1515027..1515575 + 549 WP_180372715.1 site-specific integrase -
DQL02_RS07735 1515707..1516099 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL02_RS07740 1516120..1516566 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL02_RS07745 1516784..1516990 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL02_RS07750 1516987..1517493 - 507 WP_002988070.1 hypothetical protein -
DQL02_RS07755 1517629..1518489 - 861 WP_011529009.1 DegV family protein -
DQL02_RS07760 1518586..1519104 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292415 WP_002994716.1 NZ_LS483355:1514107-1514442 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292415 WP_002988079.1 NZ_LS483355:1513830-1514117 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References