292413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1535785..1536397 Replicon chromosome
Accession NZ_LS483353
Organism Streptococcus pyogenes strain NCTC4001

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL39_RS07900 Protein ID WP_038433710.1
Coordinates 1536062..1536397 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL39_RS07895 Protein ID WP_002988079.1
Coordinates 1535785..1536072 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL39_RS07870 1530976..1531959 - 984 WP_038433707.1 tagatose-bisphosphate aldolase -
DQL39_RS07875 1531963..1532892 - 930 WP_038433708.1 tagatose-6-phosphate kinase -
DQL39_RS07880 1532938..1533453 - 516 WP_038433709.1 galactose-6-phosphate isomerase subunit LacB -
DQL39_RS07885 1533488..1533916 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQL39_RS07890 1534362..1535135 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL39_RS07895 1535785..1536072 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL39_RS07900 1536062..1536397 + 336 WP_038433710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL39_RS09085 1536549..1537019 + 471 WP_030127322.1 site-specific integrase -
DQL39_RS09090 1536982..1537530 + 549 WP_193789119.1 site-specific integrase -
DQL39_RS07915 1537662..1538054 - 393 WP_038433711.1 30S ribosomal protein S9 -
DQL39_RS07920 1538075..1538521 - 447 WP_011018228.1 50S ribosomal protein L13 -
DQL39_RS07925 1538739..1538945 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL39_RS07930 1538942..1539640 - 699 WP_011018229.1 hypothetical protein -
DQL39_RS07935 1539776..1540636 - 861 WP_002982687.1 DegV family protein -
DQL39_RS07940 1540733..1541251 - 519 WP_011889154.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13144.86 Da        Isoelectric Point: 5.2144

>T292413 WP_038433710.1 NZ_LS483353:1536062-1536397 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQNDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292413 WP_002988079.1 NZ_LS483353:1535785-1536072 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References