Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1596561..1597173 Replicon chromosome
Accession NZ_LS483352
Organism Streptococcus pyogenes strain NCTC12052

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL37_RS08325 Protein ID WP_002994716.1
Coordinates 1596838..1597173 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL37_RS08320 Protein ID WP_002988079.1
Coordinates 1596561..1596848 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL37_RS08295 1591752..1592735 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
DQL37_RS08300 1592739..1593668 - 930 WP_020837785.1 tagatose-6-phosphate kinase -
DQL37_RS08305 1593714..1594229 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQL37_RS08310 1594264..1594692 - 429 WP_002991702.1 galactose-6-phosphate isomerase subunit LacA -
DQL37_RS08315 1595138..1595911 + 774 WP_111685817.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL37_RS08320 1596561..1596848 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL37_RS08325 1596838..1597173 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL37_RS09790 1597325..1597795 + 471 Protein_1548 tyrosine-type recombinase/integrase family protein -
DQL37_RS09795 1598157..1598306 + 150 WP_011285175.1 integrase -
DQL37_RS08350 1598438..1598830 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL37_RS08355 1598851..1599297 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL37_RS08360 1599515..1599721 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL37_RS08365 1599718..1600224 - 507 WP_002988070.1 hypothetical protein -
DQL37_RS08370 1600360..1601220 - 861 WP_002982687.1 DegV family protein -
DQL37_RS08375 1601317..1601835 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292412 WP_002994716.1 NZ_LS483352:1596838-1597173 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292412 WP_002988079.1 NZ_LS483352:1596561-1596848 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References