Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1664226..1664838 Replicon chromosome
Accession NZ_LS483351
Organism Streptococcus pyogenes strain NCTC8195

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQM42_RS08810 Protein ID WP_002982731.1
Coordinates 1664503..1664838 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM42_RS08805 Protein ID WP_002988079.1
Coordinates 1664226..1664513 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM42_RS08780 1659415..1660398 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
DQM42_RS08785 1660402..1661331 - 930 WP_002982751.1 tagatose-6-phosphate kinase -
DQM42_RS08790 1661379..1661894 - 516 WP_002982748.1 galactose-6-phosphate isomerase subunit LacB -
DQM42_RS08795 1661929..1662357 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQM42_RS08800 1662803..1663576 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM42_RS08805 1664226..1664513 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM42_RS08810 1664503..1664838 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM42_RS08815 1664927..1665959 + 1033 Protein_1634 site-specific integrase -
DQM42_RS08820 1666078..1666470 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM42_RS08825 1666491..1666937 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM42_RS08830 1667230..1668213 + 984 WP_111680899.1 IS30-like element IS1239 family transposase -
DQM42_RS08835 1668241..1668447 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM42_RS08840 1668444..1668950 - 507 WP_002988070.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292411 WP_002982731.1 NZ_LS483351:1664503-1664838 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292411 WP_002988079.1 NZ_LS483351:1664226-1664513 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References