Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2140262..2140776 Replicon chromosome
Accession NZ_LS483350
Organism Staphylococcus aureus strain NCTC11940

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DQM92_RS11100 Protein ID WP_000581792.1
Coordinates 2140262..2140471 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DQM92_RS11105 Protein ID WP_000138932.1
Coordinates 2140483..2140776 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM92_RS11080 2135770..2137128 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQM92_RS11085 2137143..2138213 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
DQM92_RS11090 2138531..2139733 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DQM92_RS11095 2139997..2140134 - 138 WP_000828354.1 hypothetical protein -
DQM92_RS11100 2140262..2140471 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DQM92_RS11105 2140483..2140776 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQM92_RS11110 2140942..2142426 + 1485 WP_000571549.1 cardiolipin synthase -
DQM92_RS11115 2142454..2143101 + 648 WP_001187629.1 HD domain-containing protein -
DQM92_RS11135 2143914..2144786 - 873 WP_000725802.1 membrane protein insertase YidC -
DQM92_RS11140 2144872..2145513 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2134388..2135560 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T292405 WP_000581792.1 NZ_LS483350:c2140471-2140262 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT292405 WP_000138932.1 NZ_LS483350:c2140776-2140483 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References