292404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2119174..2119703 Replicon chromosome
Accession NZ_LS483350
Organism Staphylococcus aureus strain NCTC11940

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQM92_RS11005 Protein ID WP_000621175.1
Coordinates 2119174..2119536 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQM92_RS11010 Protein ID WP_000948331.1
Coordinates 2119533..2119703 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM92_RS10980 2116153..2116923 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
DQM92_RS10985 2116898..2117377 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQM92_RS10990 2117379..2117705 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQM92_RS10995 2117824..2118825 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQM92_RS11005 2119174..2119536 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQM92_RS11010 2119533..2119703 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQM92_RS11015 2119788..2120936 - 1149 WP_001281145.1 alanine racemase -
DQM92_RS11020 2121002..2121361 - 360 WP_000581200.1 holo-ACP synthase -
DQM92_RS11025 2121365..2121856 - 492 WP_001205910.1 PH domain-containing protein -
DQM92_RS11030 2121843..2123426 - 1584 WP_001294626.1 PH domain-containing protein -
DQM92_RS11035 2123419..2123898 - 480 WP_001287088.1 hypothetical protein -
DQM92_RS11040 2124106..2124666 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292404 WP_000621175.1 NZ_LS483350:c2119536-2119174 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292404 WP_000948331.1 NZ_LS483350:c2119703-2119533 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References