292400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1916952..1917728 Replicon chromosome
Accession NZ_LS483350
Organism Staphylococcus aureus strain NCTC11940

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQM92_RS09685 Protein ID WP_000031108.1
Coordinates 1916952..1917104 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQM92_RS09690 Protein ID WP_001251224.1
Coordinates 1917129..1917728 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM92_RS09660 1912915..1913736 + 822 WP_000669375.1 RluA family pseudouridine synthase -
DQM92_RS09665 1914199..1915584 - 1386 WP_000116224.1 class II fumarate hydratase -
DQM92_RS09670 1915780..1916175 - 396 WP_000901021.1 hypothetical protein -
DQM92_RS09685 1916952..1917104 - 153 WP_000031108.1 hypothetical protein Toxin
DQM92_RS09690 1917129..1917728 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQM92_RS09695 1917887..1918357 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQM92_RS09700 1918362..1919489 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
DQM92_RS09705 1919640..1920362 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQM92_RS09710 1920355..1921812 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292400 WP_000031108.1 NZ_LS483350:c1917104-1916952 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292400 WP_001251224.1 NZ_LS483350:c1917728-1917129 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References