292397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837692..838169 Replicon chromosome
Accession NZ_LS483350
Organism Staphylococcus aureus strain NCTC11940

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag DQM92_RS04160 Protein ID WP_000052078.1
Coordinates 837692..837880 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DQM92_RS04165 Protein ID WP_001059690.1
Coordinates 837909..838169 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM92_RS04140 834020..834490 + 471 WP_000824472.1 hypothetical protein -
DQM92_RS04145 834831..835517 + 687 WP_001548082.1 thermonuclease family protein -
DQM92_RS04150 835874..836074 + 201 WP_001059082.1 cold-shock protein -
DQM92_RS04155 836356..837528 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
DQM92_RS04160 837692..837880 - 189 WP_000052078.1 hypothetical protein Toxin
DQM92_RS04165 837909..838169 - 261 WP_001059690.1 hypothetical protein Antitoxin
DQM92_RS04170 838510..838713 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DQM92_RS04175 838710..838946 - 237 WP_000368687.1 hypothetical protein -
DQM92_RS04180 839171..839752 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
DQM92_RS04185 839825..840442 - 618 WP_000255564.1 LysE/ArgO family amino acid transporter -
DQM92_RS04190 840597..841091 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DQM92_RS04195 841490..841912 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DQM92_RS04200 842060..842776 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 836356..837528 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T292397 WP_000052078.1 NZ_LS483350:c837880-837692 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT292397 WP_001059690.1 NZ_LS483350:c838169-837909 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References