292396

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 741130..741716 Replicon chromosome
Accession NZ_LS483349
Organism Streptococcus mutans strain NCTC10449

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DQM59_RS03925 Protein ID WP_002265423.1
Coordinates 741130..741321 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H5AQZ7
Locus tag DQM59_RS03930 Protein ID WP_002269450.1
Coordinates 741339..741716 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM59_RS03910 739174..740040 + 867 WP_002280231.1 type II CRISPR-associated endonuclease Cas1 -
DQM59_RS03915 740037..740381 + 345 WP_002263547.1 CRISPR-associated endonuclease Cas2 -
DQM59_RS03920 740371..741033 + 663 WP_002263546.1 type II-A CRISPR-associated protein Csn2 -
DQM59_RS03925 741130..741321 + 192 WP_002265423.1 type II toxin-antitoxin system HicA family toxin Toxin
DQM59_RS03930 741339..741716 + 378 WP_002269450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQM59_RS03935 741814..742107 - 294 WP_142366348.1 hypothetical protein -
DQM59_RS03940 742186..743079 - 894 WP_002272311.1 LexA family transcriptional regulator IrvR -
DQM59_RS03945 743395..743679 + 285 WP_002262720.1 helix-turn-helix transcriptional regulator -
DQM59_RS03950 743842..745593 + 1752 WP_002279994.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7177.52 Da        Isoelectric Point: 10.7089

>T292396 WP_002265423.1 NZ_LS483349:741130-741321 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14293.28 Da        Isoelectric Point: 4.5628

>AT292396 WP_002269450.1 NZ_LS483349:741339-741716 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5AQZ7

References