Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1663106..1663718 Replicon chromosome
Accession NZ_LS483347
Organism Streptococcus pyogenes strain NCTC8324

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQM50_RS08690 Protein ID WP_014635711.1
Coordinates 1663383..1663718 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM50_RS08685 Protein ID WP_002988079.1
Coordinates 1663106..1663393 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM50_RS08660 1658297..1659280 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
DQM50_RS08665 1659284..1660213 - 930 WP_085613650.1 tagatose-6-phosphate kinase -
DQM50_RS08670 1660259..1660774 - 516 WP_023612880.1 galactose-6-phosphate isomerase subunit LacB -
DQM50_RS08675 1660809..1661237 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
DQM50_RS08680 1661683..1662456 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM50_RS08685 1663106..1663393 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM50_RS08690 1663383..1663718 + 336 WP_014635711.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM50_RS10045 1663870..1664340 + 471 WP_021733374.1 site-specific integrase -
DQM50_RS10050 1664303..1664851 + 549 WP_136115776.1 site-specific integrase -
DQM50_RS08700 1664971..1665363 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM50_RS08705 1665384..1665830 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM50_RS08710 1666048..1666254 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM50_RS08715 1666251..1666949 - 699 WP_168390503.1 hypothetical protein -
DQM50_RS08720 1667085..1667945 - 861 WP_011529009.1 DegV family protein -
DQM50_RS08725 1668042..1668560 - 519 WP_085613648.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13173.94 Da        Isoelectric Point: 5.6809

>T292391 WP_014635711.1 NZ_LS483347:1663383-1663718 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292391 WP_002988079.1 NZ_LS483347:1663106-1663393 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References