Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1540362..1540974 Replicon chromosome
Accession NZ_LS483345
Organism Streptococcus pyogenes strain NCTC8231

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL69_RS07815 Protein ID WP_047235979.1
Coordinates 1540639..1540974 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL69_RS07810 Protein ID WP_002988079.1
Coordinates 1540362..1540649 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL69_RS07785 1535553..1536536 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
DQL69_RS07790 1536540..1537469 - 930 Protein_1416 tagatose-6-phosphate kinase -
DQL69_RS07795 1537515..1538030 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
DQL69_RS07800 1538065..1538493 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQL69_RS07805 1538939..1539712 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL69_RS07810 1540362..1540649 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL69_RS07815 1540639..1540974 + 336 WP_047235979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL69_RS09160 1541126..1541596 + 471 Protein_1422 tyrosine-type recombinase/integrase family protein -
DQL69_RS07830 1541559..1542059 + 501 WP_111690826.1 site-specific integrase -
DQL69_RS07835 1542227..1542619 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL69_RS07840 1542640..1543086 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL69_RS07845 1543304..1543510 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL69_RS07850 1543507..1544205 - 699 WP_038431592.1 hypothetical protein -
DQL69_RS07855 1544341..1545201 - 861 WP_002982687.1 DegV family protein -
DQL69_RS07860 1545298..1545816 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13159.91 Da        Isoelectric Point: 5.2233

>T292389 WP_047235979.1 NZ_LS483345:1540639-1540974 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFEADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292389 WP_002988079.1 NZ_LS483345:1540362-1540649 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References