292386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 74906..76155 Replicon chromosome
Accession NZ_LS483343
Organism Streptococcus ferus strain NCTC12278

Toxin (Protein)


Gene name sezT Uniprot ID A0A2X3VCC2
Locus tag DQL21_RS00425 Protein ID WP_018031061.1
Coordinates 75382..76155 (+) Length 258 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DQL21_RS00420 Protein ID WP_018031062.1
Coordinates 74906..75382 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL21_RS00400 71206..72360 - 1155 WP_018031067.1 low temperature requirement protein A -
DQL21_RS00405 72574..73194 - 621 WP_018031066.1 CPBP family intramembrane metalloprotease -
DQL21_RS00410 73276..73785 - 510 WP_026162004.1 phosphatidylglycerophosphatase A -
DQL21_RS09585 73927..74067 + 141 WP_018031064.1 hypothetical protein -
DQL21_RS00415 74264..74821 + 558 WP_018031063.1 DUF1211 domain-containing protein -
DQL21_RS00420 74906..75382 + 477 WP_018031062.1 helix-turn-helix domain-containing protein Antitoxin
DQL21_RS00425 75382..76155 + 774 WP_018031061.1 zeta toxin family protein Toxin
DQL21_RS00430 76166..78406 + 2241 WP_018031060.1 AAA family ATPase -
DQL21_RS00435 78410..80434 + 2025 WP_018031059.1 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 258 a.a.        Molecular weight: 29420.32 Da        Isoelectric Point: 5.2699

>T292386 WP_018031061.1 NZ_LS483343:75382-76155 [Streptococcus ferus]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEYLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYVIDPNQARATSKEHHDGIVENLVENLRELEREQLFDQIQIYQRDRTCIYDSETDEGSAAEVLQECLFGKWSKVEEEML
KMGQERLREISVIKENL

Download         Length: 774 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.66 Da        Isoelectric Point: 4.3556

>AT292386 WP_018031062.1 NZ_LS483343:74906-75382 [Streptococcus ferus]
MIGDNIKSLRHKHHLTQPEFAEMVGISRNSLSRYENGTSTVSTELIDRICQEFNISYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDEANPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X3VCC2

Antitoxin

Source ID Structure

References