Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1571102..1571714 Replicon chromosome
Accession NZ_LS483340
Organism Streptococcus pyogenes strain NCTC12062

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL04_RS08045 Protein ID WP_047235979.1
Coordinates 1571379..1571714 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL04_RS08040 Protein ID WP_002988079.1
Coordinates 1571102..1571389 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL04_RS08015 1566293..1567276 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
DQL04_RS08020 1567280..1568209 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
DQL04_RS08025 1568255..1568770 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
DQL04_RS08030 1568805..1569233 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQL04_RS08035 1569679..1570452 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL04_RS08040 1571102..1571389 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL04_RS08045 1571379..1571714 + 336 WP_047235979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL04_RS09400 1571866..1572336 + 471 Protein_1472 tyrosine-type recombinase/integrase family protein -
DQL04_RS08060 1572299..1572799 + 501 WP_111690826.1 site-specific integrase -
DQL04_RS08065 1572967..1573359 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL04_RS08070 1573380..1573826 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL04_RS08075 1574044..1574250 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL04_RS08080 1574247..1574945 - 699 WP_038431592.1 hypothetical protein -
DQL04_RS08085 1575081..1575941 - 861 WP_002982687.1 DegV family protein -
DQL04_RS08090 1576038..1576556 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13159.91 Da        Isoelectric Point: 5.2233

>T292384 WP_047235979.1 NZ_LS483340:1571379-1571714 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFEADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292384 WP_002988079.1 NZ_LS483340:1571102-1571389 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References