Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1571277..1571889 Replicon chromosome
Accession NZ_LS483337
Organism Streptococcus pyogenes strain NCTC12047

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL03_RS08065 Protein ID WP_014635711.1
Coordinates 1571554..1571889 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL03_RS08060 Protein ID WP_002988079.1
Coordinates 1571277..1571564 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL03_RS08035 1566467..1567450 - 984 WP_014635708.1 tagatose-bisphosphate aldolase -
DQL03_RS08040 1567454..1568383 - 930 WP_063629195.1 tagatose-6-phosphate kinase -
DQL03_RS08045 1568431..1568946 - 516 WP_111675017.1 galactose-6-phosphate isomerase subunit LacB -
DQL03_RS08050 1568981..1569409 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQL03_RS08055 1569854..1570627 + 774 WP_023605292.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL03_RS08060 1571277..1571564 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL03_RS08065 1571554..1571889 + 336 WP_014635711.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL03_RS09270 1572041..1572511 + 471 WP_197708796.1 tyrosine-type recombinase/integrase family protein -
DQL03_RS09275 1572474..1573022 + 549 WP_197708797.1 site-specific integrase -
DQL03_RS08075 1573142..1573534 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL03_RS08080 1573555..1574001 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL03_RS08085 1574219..1574425 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL03_RS08090 1574422..1574928 - 507 WP_172449949.1 hypothetical protein -
DQL03_RS08095 1575064..1575924 - 861 WP_111675019.1 DegV family protein -
DQL03_RS08100 1576021..1576539 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13173.94 Da        Isoelectric Point: 5.6809

>T292382 WP_014635711.1 NZ_LS483337:1571554-1571889 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292382 WP_002988079.1 NZ_LS483337:1571277-1571564 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References