Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1671744..1672356 Replicon chromosome
Accession NZ_LS483335
Organism Streptococcus pyogenes strain NCTC8332

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQL44_RS08825 Protein ID WP_002982731.1
Coordinates 1672021..1672356 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag DQL44_RS08820 Protein ID WP_011055007.1
Coordinates 1671744..1672031 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL44_RS08795 1666935..1667918 - 984 WP_111677487.1 tagatose-bisphosphate aldolase -
DQL44_RS08800 1667922..1668851 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
DQL44_RS08805 1668897..1669412 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
DQL44_RS08810 1669447..1669875 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQL44_RS08815 1670321..1671094 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL44_RS08820 1671744..1672031 + 288 WP_011055007.1 hypothetical protein Antitoxin
DQL44_RS08825 1672021..1672356 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL44_RS10235 1672423..1673494 + 1072 Protein_1642 site-specific integrase -
DQL44_RS08845 1673626..1674018 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL44_RS08850 1674039..1674485 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL44_RS08855 1674703..1674909 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL44_RS08860 1674906..1675604 - 699 WP_011055008.1 hypothetical protein -
DQL44_RS08865 1675731..1676591 - 861 WP_111677489.1 DegV family protein -
DQL44_RS08870 1676688..1677206 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292381 WP_002982731.1 NZ_LS483335:1672021-1672356 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT292381 WP_011055007.1 NZ_LS483335:1671744-1672031 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References