Detailed information of TA system TA292380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1597321..1597933
• Replicon: chromosome
• Accession: NZ_LS483334
• Organism: Streptococcus pyogenes strain NCTC12050

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: DQL28_RS08125
• Protein ID: WP_002982731.1
• Coordinates: 1597598..1597933 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: DQL28_RS08120
• Protein ID: WP_002988079.1
• Coordinates: 1597321..1597608 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL28_RS08095	1592512..1593495	-	984	WP_111676752.1	tagatose-bisphosphate aldolase	-
DQL28_RS08100	1593499..1594428	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
DQL28_RS08105	1594474..1594989	-	516	WP_111676754.1	galactose-6-phosphate isomerase subunit LacB	-
DQL28_RS08110	1595024..1595452	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
DQL28_RS08115	1595898..1596671	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
DQL28_RS08120	1597321..1597608	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
DQL28_RS08125	1597598..1597933	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DQL28_RS09470	1598085..1598555	+	471	Protein_1509	integrase	-
DQL28_RS08140	1598518..1599066	+	549	WP_109828874.1	site-specific integrase	-
DQL28_RS08145	1599186..1599578	-	393	WP_002982716.1	30S ribosomal protein S9	-
DQL28_RS08150	1599599..1600045	-	447	WP_002982710.1	50S ribosomal protein L13	-
DQL28_RS08155	1600263..1600469	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DQL28_RS08160	1600466..1601164	-	699	WP_168688170.1	hypothetical protein	-
DQL28_RS08165	1601300..1602160	-	861	WP_002982687.1	DegV family protein	-
DQL28_RS08170	1602257..1602775	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T292380 WP_002982731.1 NZ_LS483334:1597598-1597933 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T292380 NZ_LS483334:1597598-1597933 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT292380 WP_002988079.1 NZ_LS483334:1597321-1597608 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT292380 NZ_LS483334:1597321-1597608 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94