Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1551068..1551680 Replicon chromosome
Accession NZ_LS483333
Organism Streptococcus pyogenes strain NCTC12048

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL30_RS07960 Protein ID WP_111713945.1
Coordinates 1551345..1551680 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL30_RS07955 Protein ID WP_002988079.1
Coordinates 1551068..1551355 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL30_RS07930 1546246..1547229 - 984 WP_111713943.1 tagatose-bisphosphate aldolase -
DQL30_RS07935 1547233..1548162 - 930 WP_111713944.1 tagatose-6-phosphate kinase -
DQL30_RS07940 1548210..1548725 - 516 WP_011285170.1 galactose-6-phosphate isomerase subunit LacB -
DQL30_RS07945 1548760..1549188 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQL30_RS07950 1549634..1550407 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL30_RS07955 1551068..1551355 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL30_RS07960 1551345..1551680 + 336 WP_111713945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL30_RS09190 1551832..1552302 + 471 WP_194075028.1 site-specific integrase -
DQL30_RS09195 1552663..1552812 + 150 WP_011285175.1 integrase -
DQL30_RS07970 1553329..1553667 - 339 WP_017285454.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
DQL30_RS07975 1553679..1554305 - 627 WP_170960988.1 CadD family cadmium resistance transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13238.97 Da        Isoelectric Point: 5.6809

>T292379 WP_111713945.1 NZ_LS483333:1551345-1551680 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEFRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292379 WP_002988079.1 NZ_LS483333:1551068-1551355 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References