Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1601743..1602355 Replicon chromosome
Accession NZ_LS483332
Organism Streptococcus pyogenes strain NCTC12696

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQM36_RS08385 Protein ID WP_038432559.1
Coordinates 1602020..1602355 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM36_RS08380 Protein ID WP_002988079.1
Coordinates 1601743..1602030 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM36_RS08355 1596934..1597917 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
DQM36_RS08360 1597921..1598850 - 930 WP_020837785.1 tagatose-6-phosphate kinase -
DQM36_RS08365 1598896..1599411 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQM36_RS08370 1599446..1599874 - 429 WP_038432557.1 galactose-6-phosphate isomerase subunit LacA -
DQM36_RS08375 1600320..1601093 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM36_RS08380 1601743..1602030 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM36_RS08385 1602020..1602355 + 336 WP_038432559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM36_RS09690 1602507..1602977 + 471 Protein_1548 tyrosine-type recombinase/integrase family protein -
DQM36_RS09695 1603339..1603488 + 150 WP_011285175.1 integrase -
DQM36_RS08410 1603620..1604012 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM36_RS08415 1604033..1604479 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM36_RS08420 1604697..1604903 - 207 WP_038432562.1 helix-turn-helix transcriptional regulator -
DQM36_RS08425 1604900..1605598 - 699 WP_038432565.1 hypothetical protein -
DQM36_RS08430 1605734..1606594 - 861 WP_002982687.1 DegV family protein -
DQM36_RS08435 1606691..1607209 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13159.91 Da        Isoelectric Point: 5.2144

>T292378 WP_038432559.1 NZ_LS483332:1602020-1602355 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIILYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292378 WP_002988079.1 NZ_LS483332:1601743-1602030 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References