292377

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1606048..1606660 Replicon chromosome
Accession NZ_LS483331
Organism Streptococcus pyogenes strain NCTC12057

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQL10_RS08115 Protein ID WP_002982731.1
Coordinates 1606325..1606660 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL10_RS08110 Protein ID WP_002988079.1
Coordinates 1606048..1606335 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL10_RS08085 1601226..1602209 - 984 WP_023611854.1 tagatose-bisphosphate aldolase -
DQL10_RS08090 1602213..1603142 - 930 WP_023611874.1 tagatose-6-phosphate kinase -
DQL10_RS08095 1603190..1603705 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
DQL10_RS08100 1603740..1604168 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
DQL10_RS08105 1604614..1605387 + 774 WP_002993783.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL10_RS08110 1606048..1606335 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL10_RS08115 1606325..1606660 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL10_RS09385 1606812..1607282 + 471 Protein_1491 tyrosine-type recombinase/integrase family protein -
DQL10_RS09390 1607644..1607745 + 102 WP_180372495.1 hypothetical protein -
DQL10_RS08140 1607925..1608317 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL10_RS08145 1608338..1608784 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL10_RS08150 1609002..1609208 - 207 WP_023611859.1 helix-turn-helix transcriptional regulator -
DQL10_RS08155 1609205..1609903 - 699 WP_023611871.1 hypothetical protein -
DQL10_RS08160 1610039..1610899 - 861 WP_023611214.1 DegV family protein -
DQL10_RS08165 1610996..1611514 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292377 WP_002982731.1 NZ_LS483331:1606325-1606660 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292377 WP_002988079.1 NZ_LS483331:1606048-1606335 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References