292376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1518361..1518973 Replicon chromosome
Accession NZ_LS483329
Organism Streptococcus pyogenes strain NCTC12058

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL27_RS07750 Protein ID WP_002994716.1
Coordinates 1518638..1518973 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL27_RS07745 Protein ID WP_002988079.1
Coordinates 1518361..1518648 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL27_RS07720 1513541..1514524 - 984 WP_111711469.1 tagatose-bisphosphate aldolase -
DQL27_RS07725 1514528..1515457 - 930 WP_111711470.1 tagatose-6-phosphate kinase -
DQL27_RS07730 1515505..1516020 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQL27_RS07735 1516055..1516483 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQL27_RS07740 1516927..1517700 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL27_RS07745 1518361..1518648 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL27_RS07750 1518638..1518973 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL27_RS09070 1519125..1519595 + 471 WP_021733374.1 site-specific integrase -
DQL27_RS09075 1519558..1520106 + 549 WP_180372715.1 site-specific integrase -
DQL27_RS07765 1520238..1520630 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL27_RS07770 1520651..1521097 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL27_RS07775 1521315..1521521 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL27_RS07780 1521518..1522024 - 507 WP_002988070.1 hypothetical protein -
DQL27_RS07785 1522160..1523020 - 861 WP_011529009.1 DegV family protein -
DQL27_RS07790 1523150..1523635 - 486 WP_111711471.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292376 WP_002994716.1 NZ_LS483329:1518638-1518973 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292376 WP_002988079.1 NZ_LS483329:1518361-1518648 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References