Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1561799..1562411 Replicon chromosome
Accession NZ_LS483327
Organism Streptococcus pyogenes strain NCTC12069

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL07_RS08115 Protein ID WP_002994716.1
Coordinates 1562076..1562411 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL07_RS08110 Protein ID WP_002988079.1
Coordinates 1561799..1562086 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL07_RS08085 1556990..1557973 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
DQL07_RS08090 1557977..1558906 - 930 WP_020837785.1 tagatose-6-phosphate kinase -
DQL07_RS08095 1558952..1559467 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQL07_RS08100 1559502..1559930 - 429 WP_002991702.1 galactose-6-phosphate isomerase subunit LacA -
DQL07_RS08105 1560376..1561149 + 774 WP_023605292.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL07_RS08110 1561799..1562086 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL07_RS08115 1562076..1562411 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL07_RS09450 1562563..1563033 + 471 WP_021733374.1 site-specific integrase -
DQL07_RS09455 1562996..1563544 + 549 WP_136115776.1 site-specific integrase -
DQL07_RS08125 1563664..1564056 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL07_RS08130 1564077..1564523 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL07_RS08135 1564741..1564947 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL07_RS08140 1564944..1565642 - 699 WP_023605294.1 hypothetical protein -
DQL07_RS08145 1565778..1566638 - 861 WP_002982687.1 DegV family protein -
DQL07_RS08150 1566735..1567253 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292375 WP_002994716.1 NZ_LS483327:1562076-1562411 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292375 WP_002988079.1 NZ_LS483327:1561799-1562086 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References