Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1572892..1574138 Replicon chromosome
Accession NZ_LS483325
Organism Streptococcus equi subsp. zooepidemicus strain NCTC7022

Toxin (Protein)


Gene name sezT Uniprot ID A0A2X3SC14
Locus tag DQL35_RS07535 Protein ID WP_043029978.1
Coordinates 1572892..1573662 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A2X3RVP4
Locus tag DQL35_RS07540 Protein ID WP_043029979.1
Coordinates 1573662..1574138 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL35_RS07505 1568170..1569972 - 1803 WP_043029728.1 excisionase -
DQL35_RS07510 1570545..1570937 - 393 Protein_1438 relaxase/mobilization nuclease domain-containing protein -
DQL35_RS07515 1570924..1571289 - 366 WP_043029976.1 MobC family plasmid mobilization relaxosome protein -
DQL35_RS07520 1571299..1571658 - 360 WP_043029977.1 hypothetical protein -
DQL35_RS10715 1572030..1572398 - 369 WP_052495489.1 hypothetical protein -
DQL35_RS10720 1572389..1572889 - 501 WP_052495490.1 hypothetical protein -
DQL35_RS07535 1572892..1573662 - 771 WP_043029978.1 zeta toxin family protein Toxin
DQL35_RS07540 1573662..1574138 - 477 WP_043029979.1 helix-turn-helix domain-containing protein Antitoxin
DQL35_RS07545 1574208..1574495 - 288 WP_038674119.1 hypothetical protein -
DQL35_RS07550 1574540..1574935 - 396 WP_043029980.1 hypothetical protein -
DQL35_RS07555 1574939..1575166 - 228 WP_043029981.1 hypothetical protein -
DQL35_RS07560 1575220..1576308 - 1089 WP_043029982.1 toprim domain-containing protein -
DQL35_RS07565 1576347..1576985 - 639 WP_043030011.1 hypothetical protein -
DQL35_RS07570 1577098..1578360 - 1263 WP_043029983.1 polysaccharide biosynthesis C-terminal domain-containing protein -
DQL35_RS07575 1578360..1578680 - 321 WP_043029984.1 PqqD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1548629..1591688 43059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29098.88 Da        Isoelectric Point: 5.8780

>T292373 WP_043029978.1 NZ_LS483325:c1573662-1572892 [Streptococcus equi subsp. zooepidemicus]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDDLSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Download         Length: 771 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18046.41 Da        Isoelectric Point: 4.3193

>AT292373 WP_043029979.1 NZ_LS483325:c1574138-1573662 [Streptococcus equi subsp. zooepidemicus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKIE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X3SC14

Antitoxin

Source ID Structure
AlphaFold DB A0A2X3RVP4

References