Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2161496..2162025 Replicon chromosome
Accession NZ_LS483324
Organism Staphylococcus aureus strain NCTC10344

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL79_RS11250 Protein ID WP_000621175.1
Coordinates 2161496..2161858 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL79_RS11255 Protein ID WP_000948331.1
Coordinates 2161855..2162025 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL79_RS11225 2158474..2159244 - 771 Protein_2072 RNA polymerase sigma factor SigB -
DQL79_RS11230 2159219..2159698 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQL79_RS11235 2159700..2160026 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL79_RS11240 2160145..2161146 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQL79_RS11250 2161496..2161858 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL79_RS11255 2161855..2162025 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL79_RS11260 2162110..2163258 - 1149 WP_001281154.1 alanine racemase -
DQL79_RS11265 2163324..2163683 - 360 WP_000581197.1 holo-ACP synthase -
DQL79_RS11270 2163687..2164178 - 492 WP_001205912.1 PH domain-containing protein -
DQL79_RS11275 2164165..2165748 - 1584 WP_001294620.1 PH domain-containing protein -
DQL79_RS11280 2165741..2166220 - 480 WP_001836941.1 hypothetical protein -
DQL79_RS11285 2166429..2166989 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292368 WP_000621175.1 NZ_LS483324:c2161858-2161496 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292368 WP_000948331.1 NZ_LS483324:c2162025-2161855 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References