Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1497043..1497655 Replicon chromosome
Accession NZ_LS483322
Organism Streptococcus pyogenes strain NCTC12066

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL05_RS07625 Protein ID WP_023080134.1
Coordinates 1497320..1497655 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL05_RS07620 Protein ID WP_002988079.1
Coordinates 1497043..1497330 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL05_RS07595 1492234..1493217 - 984 WP_030126795.1 tagatose-bisphosphate aldolase -
DQL05_RS07600 1493221..1494150 - 930 WP_030126796.1 tagatose-6-phosphate kinase -
DQL05_RS07605 1494196..1494711 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
DQL05_RS07610 1494746..1495174 - 429 WP_002991702.1 galactose-6-phosphate isomerase subunit LacA -
DQL05_RS07615 1495620..1496393 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL05_RS07620 1497043..1497330 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL05_RS07625 1497320..1497655 + 336 WP_023080134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL05_RS08940 1497807..1498277 + 471 Protein_1398 integrase -
DQL05_RS07640 1498240..1498788 + 549 WP_109828874.1 site-specific integrase -
DQL05_RS07645 1498908..1499300 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL05_RS07650 1499321..1499767 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL05_RS07655 1499985..1500191 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL05_RS07660 1500188..1500694 - 507 WP_002988070.1 hypothetical protein -
DQL05_RS07665 1500830..1501690 - 861 WP_002982687.1 DegV family protein -
DQL05_RS07670 1501787..1502305 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13159.91 Da        Isoelectric Point: 5.2233

>T292360 WP_023080134.1 NZ_LS483322:1497320-1497655 [Streptococcus pyogenes]
MDYKKYQIIYAPEVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292360 WP_002988079.1 NZ_LS483322:1497043-1497330 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References