Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2260104..2260633 Replicon chromosome
Accession NZ_LS483319
Organism Staphylococcus aureus strain NCTC13140

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL82_RS12020 Protein ID WP_000621175.1
Coordinates 2260104..2260466 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL82_RS12025 Protein ID WP_000948331.1
Coordinates 2260463..2260633 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL82_RS11995 2257083..2257853 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
DQL82_RS12000 2257828..2258307 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQL82_RS12005 2258309..2258635 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL82_RS12010 2258754..2259755 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQL82_RS12020 2260104..2260466 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL82_RS12025 2260463..2260633 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL82_RS12030 2260718..2261866 - 1149 WP_001281145.1 alanine racemase -
DQL82_RS12035 2261932..2262291 - 360 WP_000581200.1 holo-ACP synthase -
DQL82_RS12040 2262295..2262786 - 492 WP_001205910.1 PH domain-containing protein -
DQL82_RS12045 2262773..2264356 - 1584 WP_001294626.1 PH domain-containing protein -
DQL82_RS12050 2264349..2264828 - 480 WP_001287088.1 hypothetical protein -
DQL82_RS12055 2265036..2265596 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292349 WP_000621175.1 NZ_LS483319:c2260466-2260104 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292349 WP_000948331.1 NZ_LS483319:c2260633-2260463 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References