Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1170035..1170811 Replicon chromosome
Accession NZ_LS483319
Organism Staphylococcus aureus strain NCTC13140

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL82_RS06175 Protein ID WP_000031108.1
Coordinates 1170659..1170811 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQL82_RS06170 Protein ID WP_001251224.1
Coordinates 1170035..1170634 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL82_RS06150 1165951..1167408 + 1458 WP_000649907.1 ABC transporter permease subunit -
DQL82_RS06155 1167401..1168123 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQL82_RS06160 1168274..1169401 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL82_RS06165 1169406..1169876 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL82_RS06170 1170035..1170634 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQL82_RS06175 1170659..1170811 + 153 WP_000031108.1 hypothetical protein Toxin
DQL82_RS06190 1171482..1172654 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
DQL82_RS06195 1172920..1173315 + 396 WP_000901021.1 hypothetical protein -
DQL82_RS06200 1173511..1174896 + 1386 WP_000116224.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1171482..1172654 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292344 WP_000031108.1 NZ_LS483319:1170659-1170811 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292344 WP_001251224.1 NZ_LS483319:1170035-1170634 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References