292337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2155075..2155589 Replicon chromosome
Accession NZ_LS483317
Organism Staphylococcus aureus strain NCTC5663

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag DQL75_RS11045 Protein ID WP_111762523.1
Coordinates 2155075..2155284 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag DQL75_RS11050 Protein ID WP_000138934.1
Coordinates 2155296..2155589 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL75_RS11025 2150583..2151941 - 1359 WP_111762520.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQL75_RS11030 2151956..2153026 - 1071 WP_111762521.1 D-alanine--D-alanine ligase -
DQL75_RS11035 2153344..2154546 + 1203 WP_111762522.1 rod shape-determining protein RodA -
DQL75_RS11040 2154810..2154947 - 138 WP_000828354.1 hypothetical protein -
DQL75_RS11045 2155075..2155284 - 210 WP_111762523.1 heavy-metal-associated domain-containing protein Toxin
DQL75_RS11050 2155296..2155589 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL75_RS11055 2155769..2157253 + 1485 WP_111762524.1 cardiolipin synthase -
DQL75_RS11060 2157281..2157928 + 648 WP_111762525.1 HD domain-containing protein -
DQL75_RS11070 2158694..2159566 - 873 WP_000725802.1 membrane protein insertase YidC -
DQL75_RS11075 2159652..2160293 - 642 WP_111762527.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7885.85 Da        Isoelectric Point: 4.1008

>T292337 WP_111762523.1 NZ_LS483317:c2155284-2155075 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVIVSYETPANLNSIEKEIYDEGYKILF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT292337 WP_000138934.1 NZ_LS483317:c2155589-2155296 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References