Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2135335..2135864 Replicon chromosome
Accession NZ_LS483317
Organism Staphylococcus aureus strain NCTC5663

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL75_RS10955 Protein ID WP_000621175.1
Coordinates 2135335..2135697 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL75_RS10960 Protein ID WP_000948331.1
Coordinates 2135694..2135864 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL75_RS10930 2132313..2133083 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DQL75_RS10935 2133058..2133537 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DQL75_RS10940 2133539..2133865 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL75_RS10945 2133984..2134985 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQL75_RS10955 2135335..2135697 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL75_RS10960 2135694..2135864 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL75_RS10965 2135949..2137097 - 1149 WP_111762513.1 alanine racemase -
DQL75_RS10970 2137163..2137522 - 360 WP_000581197.1 holo-ACP synthase -
DQL75_RS10975 2137526..2138017 - 492 WP_078316666.1 PH domain-containing protein -
DQL75_RS10980 2138004..2139587 - 1584 WP_111762514.1 PH domain-containing protein -
DQL75_RS10985 2139580..2140059 - 480 WP_111762515.1 hypothetical protein -
DQL75_RS10990 2140268..2140828 - 561 WP_111762516.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292336 WP_000621175.1 NZ_LS483317:c2135697-2135335 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292336 WP_000948331.1 NZ_LS483317:c2135864-2135694 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References