Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 1967451..1968228 | Replicon | chromosome |
Accession | NZ_LS483317 | ||
Organism | Staphylococcus aureus strain NCTC5663 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | X5E2E6 |
Locus tag | DQL75_RS09940 | Protein ID | WP_000031108.1 |
Coordinates | 1967451..1967603 (-) | Length | 51 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | A0A0D1IYN8 |
Locus tag | DQL75_RS09945 | Protein ID | WP_001251219.1 |
Coordinates | 1967629..1968228 (-) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DQL75_RS09915 | 1963353..1964174 | + | 822 | WP_000669380.1 | RluA family pseudouridine synthase | - |
DQL75_RS09920 | 1964639..1966024 | - | 1386 | WP_000116236.1 | class II fumarate hydratase | - |
DQL75_RS09925 | 1966220..1966615 | - | 396 | WP_111762458.1 | hypothetical protein | - |
DQL75_RS09940 | 1967451..1967603 | - | 153 | WP_000031108.1 | hypothetical protein | Toxin |
DQL75_RS09945 | 1967629..1968228 | - | 600 | WP_001251219.1 | glucosamine-6-phosphate isomerase | Antitoxin |
DQL75_RS09950 | 1968387..1968857 | - | 471 | WP_111762461.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
DQL75_RS09955 | 1968862..1969989 | - | 1128 | WP_000379980.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
DQL75_RS09960 | 1970140..1970862 | - | 723 | WP_049296713.1 | amino acid ABC transporter ATP-binding protein | - |
DQL75_RS09965 | 1970855..1972312 | - | 1458 | WP_111762462.1 | ABC transporter permease subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5936.28 Da Isoelectric Point: 3.8962
>T292335 WP_000031108.1 NZ_LS483317:c1967603-1967451 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
Download Length: 153 bp
Antitoxin
Download Length: 200 a.a. Molecular weight: 22357.50 Da Isoelectric Point: 5.1445
>AT292335 WP_001251219.1 NZ_LS483317:c1968228-1967629 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | X5E2E6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D1IYN8 |