Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1570561..1571173 Replicon chromosome
Accession NZ_LS483315
Organism Streptococcus pyogenes strain NCTC12059

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag DQL11_RS08030 Protein ID WP_002988077.1
Coordinates 1570838..1571173 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL11_RS08025 Protein ID WP_002988079.1
Coordinates 1570561..1570848 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL11_RS08000 1565752..1566735 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
DQL11_RS08005 1566739..1567668 - 930 WP_111704783.1 tagatose-6-phosphate kinase -
DQL11_RS08010 1567714..1568229 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
DQL11_RS08015 1568264..1568692 - 429 WP_111704784.1 galactose-6-phosphate isomerase subunit LacA -
DQL11_RS08020 1569138..1569911 + 774 WP_023605292.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL11_RS08025 1570561..1570848 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL11_RS08030 1570838..1571173 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL11_RS08035 1571262..1572306 + 1045 Protein_1471 site-specific integrase -
DQL11_RS08040 1572426..1572818 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL11_RS08045 1572839..1573285 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL11_RS08050 1573503..1573709 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQL11_RS08055 1573706..1574212 - 507 WP_172449835.1 hypothetical protein -
DQL11_RS08060 1574348..1575208 - 861 WP_002982687.1 DegV family protein -
DQL11_RS08065 1575305..1575823 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T292315 WP_002988077.1 NZ_LS483315:1570838-1571173 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292315 WP_002988079.1 NZ_LS483315:1570561-1570848 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References