Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2121861..2122375 Replicon chromosome
Accession NZ_LS483314
Organism Staphylococcus aureus strain NCTC3761

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DQL90_RS10945 Protein ID WP_000581792.1
Coordinates 2121861..2122070 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DQL90_RS10950 Protein ID WP_000138932.1
Coordinates 2122082..2122375 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL90_RS10925 2117369..2118727 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQL90_RS10930 2118742..2119812 - 1071 WP_111688672.1 D-alanine--D-alanine ligase -
DQL90_RS10935 2120130..2121332 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DQL90_RS10940 2121596..2121733 - 138 WP_000828354.1 hypothetical protein -
DQL90_RS10945 2121861..2122070 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DQL90_RS10950 2122082..2122375 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL90_RS10955 2122541..2124025 + 1485 WP_000571549.1 cardiolipin synthase -
DQL90_RS10960 2124053..2124700 + 648 WP_001187630.1 HD domain-containing protein -
DQL90_RS10975 2125305..2126177 - 873 WP_000725802.1 membrane protein insertase YidC -
DQL90_RS10980 2126263..2126904 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T292311 WP_000581792.1 NZ_LS483314:c2122070-2121861 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT292311 WP_000138932.1 NZ_LS483314:c2122375-2122082 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References