Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1929148..1929924 Replicon chromosome
Accession NZ_LS483314
Organism Staphylococcus aureus strain NCTC3761

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL90_RS09780 Protein ID WP_000031108.1
Coordinates 1929148..1929300 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQL90_RS09785 Protein ID WP_001251224.1
Coordinates 1929325..1929924 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL90_RS09760 1925355..1926176 + 822 WP_000669376.1 RluA family pseudouridine synthase -
DQL90_RS09765 1926628..1928013 - 1386 WP_000116229.1 class II fumarate hydratase -
DQL90_RS09770 1928209..1928604 - 396 WP_000901023.1 hypothetical protein -
DQL90_RS09780 1929148..1929300 - 153 WP_000031108.1 hypothetical protein Toxin
DQL90_RS09785 1929325..1929924 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQL90_RS09790 1930083..1930553 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL90_RS09795 1930558..1931685 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL90_RS09800 1931837..1932559 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQL90_RS09805 1932552..1934009 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1934308..1935627 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292308 WP_000031108.1 NZ_LS483314:c1929300-1929148 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292308 WP_001251224.1 NZ_LS483314:c1929924-1929325 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References