Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1051213..1051727 Replicon chromosome
Accession NZ_LS483313
Organism Staphylococcus simulans strain NCTC11046

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL89_RS04785 Protein ID WP_031262808.1
Coordinates 1051377..1051727 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4QNU3
Locus tag DQL89_RS04780 Protein ID WP_023016097.1
Coordinates 1051213..1051380 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL89_RS04755 1047103..1047567 + 465 WP_060804059.1 PH domain-containing protein -
DQL89_RS04760 1047560..1049053 + 1494 WP_070626487.1 PH domain-containing protein -
DQL89_RS04765 1049046..1049543 + 498 WP_070626486.1 PH domain-containing protein -
DQL89_RS04770 1049545..1049898 + 354 WP_070626517.1 holo-ACP synthase -
DQL89_RS04775 1049978..1051132 + 1155 WP_070626485.1 alanine racemase -
DQL89_RS04780 1051213..1051380 + 168 WP_023016097.1 hypothetical protein Antitoxin
DQL89_RS04785 1051377..1051727 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL89_RS04790 1052019..1053020 + 1002 WP_002481750.1 PP2C family protein-serine/threonine phosphatase -
DQL89_RS04795 1053096..1053422 + 327 WP_002481749.1 anti-sigma factor antagonist -
DQL89_RS04800 1053424..1053903 + 480 WP_023016096.1 anti-sigma B factor RsbW -
DQL89_RS04805 1053878..1054648 + 771 WP_002481747.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T292306 WP_031262808.1 NZ_LS483313:1051377-1051727 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6257.78 Da        Isoelectric Point: 3.6836

>AT292306 WP_023016097.1 NZ_LS483313:1051213-1051380 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4QNU3

References