Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1037916..1038430 Replicon chromosome
Accession NZ_LS483313
Organism Staphylococcus simulans strain NCTC11046

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag DQL89_RS04720 Protein ID WP_002481764.1
Coordinates 1038224..1038430 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag DQL89_RS04715 Protein ID WP_002481765.1
Coordinates 1037916..1038209 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL89_RS04690 1033311..1033949 + 639 WP_070626492.1 thiamine phosphate synthase -
DQL89_RS04695 1034038..1034907 + 870 WP_002481769.1 membrane protein insertase YidC -
DQL89_RS04700 1035033..1035545 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
DQL89_RS04705 1035602..1036252 - 651 WP_060804054.1 HD domain-containing protein -
DQL89_RS04710 1036276..1037757 - 1482 WP_023016108.1 cardiolipin synthase -
DQL89_RS04715 1037916..1038209 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL89_RS04720 1038224..1038430 + 207 WP_002481764.1 heavy-metal-associated domain-containing protein Toxin
DQL89_RS04725 1038449..1038655 + 207 WP_002481763.1 copper ion binding protein -
DQL89_RS04730 1038747..1040939 + 2193 WP_070626490.1 heavy metal translocating P-type ATPase -
DQL89_RS13435 1041021..1041161 + 141 WP_023016106.1 hypothetical protein -
DQL89_RS04735 1041221..1042429 - 1209 WP_103363762.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T292305 WP_002481764.1 NZ_LS483313:1038224-1038430 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT292305 WP_002481765.1 NZ_LS483313:1037916-1038209 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References