292304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1111512..1112321 Replicon chromosome
Accession NZ_LS483312
Organism Staphylococcus lugdunensis strain NCTC7990

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag DQL63_RS05340 Protein ID WP_002458758.1
Coordinates 1112151..1112321 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A853V5R2
Locus tag DQL63_RS05335 Protein ID WP_002458757.1
Coordinates 1111512..1112111 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL63_RS05315 1107106..1108563 + 1458 WP_002477974.1 ABC transporter substrate-binding protein/permease -
DQL63_RS05320 1108556..1109281 + 726 WP_002458754.1 amino acid ABC transporter ATP-binding protein -
DQL63_RS05325 1109732..1110874 + 1143 WP_002458755.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL63_RS05330 1110876..1111346 + 471 WP_002458756.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL63_RS05335 1111512..1112111 + 600 WP_002458757.1 glucosamine-6-phosphate isomerase Antitoxin
DQL63_RS05340 1112151..1112321 + 171 WP_002458758.1 hypothetical protein Toxin
DQL63_RS05345 1112495..1112890 + 396 WP_002458759.1 hypothetical protein -
DQL63_RS05350 1113018..1114403 + 1386 WP_002458760.1 class II fumarate hydratase -
DQL63_RS05355 1114468..1115304 - 837 WP_002458761.1 RluA family pseudouridine synthase -
DQL63_RS05360 1115472..1116584 + 1113 WP_037542869.1 GAF domain-containing sensor histidine kinase -
DQL63_RS05365 1116606..1117229 + 624 WP_002458763.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6565.10 Da        Isoelectric Point: 4.6723

>T292304 WP_002458758.1 NZ_LS483312:1112151-1112321 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Download         Length: 171 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22619.51 Da        Isoelectric Point: 4.9539

>AT292304 WP_002458757.1 NZ_LS483312:1111512-1112111 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V5R2

References