Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 971718..972235 Replicon chromosome
Accession NZ_LS483312
Organism Staphylococcus lugdunensis strain NCTC7990

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag DQL63_RS04550 Protein ID WP_002461192.1
Coordinates 971885..972235 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag DQL63_RS04545 Protein ID WP_002461193.1
Coordinates 971718..971888 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL63_RS04520 967543..968025 + 483 WP_037543569.1 PH domain-containing protein -
DQL63_RS04525 968018..969532 + 1515 WP_002461198.1 PH domain-containing protein -
DQL63_RS04530 969519..970031 + 513 WP_002461197.1 PH domain-containing protein -
DQL63_RS04535 970043..970435 + 393 WP_002461196.1 holo-ACP synthase -
DQL63_RS04540 970483..971631 + 1149 WP_037543565.1 alanine racemase -
DQL63_RS04545 971718..971888 + 171 WP_002461193.1 hypothetical protein Antitoxin
DQL63_RS04550 971885..972235 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL63_RS04555 972669..973670 + 1002 WP_111703859.1 PP2C family protein-serine/threonine phosphatase -
DQL63_RS04560 973761..974087 + 327 WP_002461190.1 anti-sigma factor antagonist -
DQL63_RS04565 974089..974568 + 480 WP_012990787.1 anti-sigma B factor RsbW -
DQL63_RS04570 974543..975313 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T292303 WP_002461192.1 NZ_LS483312:971885-972235 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp


Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT292303 WP_002461193.1 NZ_LS483312:971718-971888 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A853V3R6


Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References