Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 960317..960835 Replicon chromosome
Accession NZ_LS483312
Organism Staphylococcus lugdunensis strain NCTC7990

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133Q814
Locus tag DQL63_RS04490 Protein ID WP_002461207.1
Coordinates 960623..960835 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag DQL63_RS04485 Protein ID WP_002492098.1
Coordinates 960317..960610 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL63_RS04465 955917..956555 + 639 WP_002461213.1 thiamine phosphate synthase -
DQL63_RS04470 956645..957520 + 876 WP_002461212.1 membrane protein insertase YidC -
DQL63_RS04475 957904..958545 - 642 WP_002492092.1 HD domain-containing protein -
DQL63_RS04480 958667..960151 - 1485 WP_002461210.1 cardiolipin synthase -
DQL63_RS04485 960317..960610 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL63_RS04490 960623..960835 + 213 WP_002461207.1 heavy-metal-associated domain-containing protein Toxin
DQL63_RS04495 960926..961063 + 138 WP_002461206.1 hypothetical protein -
DQL63_RS04500 961477..962667 - 1191 WP_002461205.1 rod shape-determining protein RodA -
DQL63_RS04505 963023..964093 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
DQL63_RS04510 964111..965469 + 1359 WP_002461203.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8069.09 Da        Isoelectric Point: 4.1677

>T292302 WP_002461207.1 NZ_LS483312:960623-960835 [Staphylococcus lugdunensis]
VEKRLIYITNVTSEDDLKNLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT292302 WP_002492098.1 NZ_LS483312:960317-960610 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133Q814

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References