Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2175737..2176266 Replicon chromosome
Accession NZ_LS483311
Organism Staphylococcus aureus strain NCTC6136

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL83_RS11485 Protein ID WP_000621175.1
Coordinates 2175737..2176099 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL83_RS11490 Protein ID WP_000948331.1
Coordinates 2176096..2176266 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL83_RS11460 2172716..2173486 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
DQL83_RS11465 2173461..2173940 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQL83_RS11470 2173942..2174268 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL83_RS11475 2174387..2175388 - 1002 WP_111724430.1 PP2C family protein-serine/threonine phosphatase -
DQL83_RS11485 2175737..2176099 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL83_RS11490 2176096..2176266 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL83_RS11495 2176351..2177499 - 1149 WP_001281154.1 alanine racemase -
DQL83_RS11500 2177565..2177924 - 360 WP_000581197.1 holo-ACP synthase -
DQL83_RS11505 2177928..2178419 - 492 WP_001205917.1 PH domain-containing protein -
DQL83_RS11510 2178406..2179989 - 1584 WP_001294626.1 PH domain-containing protein -
DQL83_RS11515 2179982..2180461 - 480 WP_001287086.1 hypothetical protein -
DQL83_RS11520 2180670..2181230 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292295 WP_000621175.1 NZ_LS483311:c2176099-2175737 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292295 WP_000948331.1 NZ_LS483311:c2176266-2176096 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References